Binds to the E2 (gp53) protein of Bovine Viral Diarrhea Virus Type 1 (BVDV-1) and to Bovine Viral Diarrhea Virus Type 2 (BVDV-2). IgG2b isotype. Can be used as a reagent to detect both BVDV-1 and BVDV-2 using indirect immunofluoresence or indirect immunoperoxidase reactions. This monoclonal antibody has also been used in virus neutralization assays. This monoclonal antibody is produced as mouse ascites fluid, clarified by centrifugation, and filtered through a 0.2 micrometer filter. The concentration is 1.0 mg/ml in phosphate-buffered saline, containing 4 mg/ml BSA, preserved with sodium azide.
Note: BVDV-1 genotypes usually produce only mild diarrhea in immunocompetent cattle, while BVDV-2 genotypes can produce thrombocytopenia, hemorrhages, and acute fatal disease. The viruses of either genotype may exist as one of two biotypes, cytopathic or noncytopathic. This product does not work with formalin fixed tissue.